Selected Publications


  1. Kishore V. Kuchibhotla, Tom Hindmarsh Sten, Eleni S. Papadoyannis, Sarah Elnozahy, Kelly A. Fogelson, Rupesh Kumar, Yves Boubenec, Peter C. Holland, Srdjan Ostojic & Robert C. Froemke. Dissociating task acquisition from expression during learning reveals latent knowledge. Nature Communications 2019; 10:2151.

  2. Ioana Carcea, Robert C. Froemke. Biological mechanisms for observational learning. Current Opinion in Neurobiology 2019, 54:178–185.

  3. Michele N. Insanally, Ioana Carcea, Rachel E. Field, Chris C. Rodgers, Brian DePasquale, Kanaka Rajan, Michael R. DeWeese, Badr F. Albanna & Robert Froemke. Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons. eLife 2019; 8:e42409.



  1. Silvana Valtcheva, Robert C. Froemke. Neuromodulation of maternal circuits by oxytocin. Cell Tissue Res 2019; 375(1):57-68. 

  2. Virginia Woods, Michael Trumpis, Brinnae Bent, Kay Palopoli-Trojani, Chia-Han Chiang, Charles Wang,  Chunxiu Yu, Michele N Insanally, Robert C Froemke, and Jonathan Viventi. Long-term recording reliability of liquid crystal polymer µECoG arrays. Journal of Neural Engineering. 2018 ; 15(6):066024.

  3. Natasha N. Tirko, Katherine W. Eyring, Ioana Carcea, Mariela Mitre, Moses V. Chao, Robert C. Froemke, and Richard W. Tsien. Oxytocin Transforms Firing Mode of CA2 Hippocampal Neurons. Neuron; 100(3):593-608.

  4. Erin Glennon, Ioana Carcea, Ana Raquel O. Martins, Jasmin Multani, Ina Shehu, Mario A. Svirsky, Robert C. Froemke. Locus coeruleus activation accelerates perceptual learning.  Brain Research 2018; S0006-8993(18)30324-X.

  5. Anita C Hansson, Anne Koopmann , Stefanie Uhrig , Sina Bühler, Esi Domi, Eva Kiessling , Roberto Ciccocioppo, Robert C Froemke , Valery Grinevich , Falk Kiefer , Wolfgang H Sommer, Sabine Vollstädt-Klein, and Rainer Spanagel. Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans. Neuropsychopharmacology 2018 ;43(6):1235-1246. 

  6. Mariela Mitre, Jessica Minder, Egzona X. Morina, Moses V. Chao, and Robert C. Froemke. Oxytocin Modulation of Neural Circuits. Curr Top Behav Neurosci. 2018 ; 35: 31–53.



  1. Carcea I, Insanally MN & Froemke RC. Dynamics of cortical activity during behavioral engagement and auditory perception. Nature Communications 2017; 8(14412), 1038.

  2. Kuchibhotla KV, Gill JV, Lindsay GW, Field RE, Papadoyannis ES, Hindmarsh Sten TA, Miller KD & Froemke RC. Parallel processing by cortical inhibition enables context-dependent behavior. Nature Neuroscience 2017; 20(1), 62-71. Code for simulations.



  1. King J, Shehu I, Roland JT Jr, Svirsky MA & Froemke RC. A physiological and behavioral system for hearing restoration with cochlear implants. Journal of Neurophysiology 2016; 116(2), 844-858.
  2. Mitre M, Marlin BJ, Schiavo JK, Morina E, Norden SE, Hackett TA, Chao MV & Froemke RC. A distributed network for social cognition enriched for oxytocin receptors. Journal of Neuroscience 2016; 36(8), 2517-2535.
  3. Insanally M, Trumpis M, Wang C, Chiang CH, Woods V, Palopoli-Trojani K, Bossi S, Froemke RC & Viventi J. A low-cost, multiplexed ECoG system for high-density recording in freely moving rodents. Journal of Neural Engineering 2016; 13(2), 026030.
  4. Oetti LL, Ravi N, Schneider M, Scheller MF, Schneider P, Mitre M, da Silva Gouveia, Froemke RC, Chao MV, Young WS, Meyer-Lindenberg A, Grinevich V, Shusterman R, Kelsch W. Oxytocin enhances scoial recognition by modulating cortical control of early olfactory processing. Neuron 2016; 90(3): 609–621.
  5. Cohen SM, Ma H, Kuchibhotla KV, Watson BO, Buzsáki G, Froemke RC & Tsien RW. Excitation-Transcription coupling in parvalbumin-positive interneurons employs a novel CaM kinase-dependent pathway distinct from excitatory neurons. Neuron 2016; 90(2), 292-307.
  6. Eliava M, Melchior M, Knobloch-Bollman HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, del Rio RT, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, SPrengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop Rm Charlet A & Grinevich V. A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron 2016; 89(6), 1291-1304 .



  1. Marlin BJ, Mitre M, D'amour JA, Chao MV, Froemke RC. Oxytocin enables maternal behavior by balancing cortical inhibition. Nature 2015; 520:499-504.
  3. Martins ARO, Froemke RC. Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex. Nature Neuroscience 2015; 18(10), 1483-1492.
  5. D'amour JA, Froemke RC. Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex. Neuron 2015; 86:514-528. Download data.
  7. Froemke RC. Plasticity of cortical excitatory-inhibitory balance. Annual Review of Neuroscience. Annual Review of Neuroscience 2015; 38:195-219.
  9. Froemke RC, Schreiner CE. Synaptic plasticity as a cortical coding scheme. Current Opinion in Neurobiology 2015; 35, 185-199.
  11. King J, Insanally M, Jin M, Martins ARO, D'amour JA, Froemke RC. Rodent auditory perception: Critical band limitations and plasticity. Neuroscience 2015; 296:55-65.
  13. Costa RP, Froemke RC, Sjöström PJ,  van Rossum MCW. Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife 2015;10.7554/eLife.09457
  15. Lee M, Manders TM, Eberle S, Su C, D’amour JA, Deisseroth K, Froemke RC, Wang J. Activation of corticostriatal circuitry relieves pain. Journal of Neuroscience 2015; 35:5247-5259.



  1. Gomez AM, Froemke RC, Burden SJ. Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. eLife 2014; 3.
  3. Carcea I, Patil SB, Robison AJ, Mesias R, Mortillo S, Huntsman MM, Froemke RC, Buxbaum JD, Huntley GW, Benson DL. Maturation of cortical circuits requires Sema7A. Proceedings of the National Academy of Science USA 2014; 111:13978-13983.



  1. Carcea I, Froemke RC. Cortical plasticity, excitatory-inhibitory balance, and sensory perception. Progress in Brain Research 2013 207:65-90.
  3. Vogels TP, Froemke RC, Doyon N, Gilson M, Haas J, Liu R, Maffei A, Miller P, Wierenga C, Woodin M, Zenke F, Sprekeler H. Inhibitory synaptic plasticity: Spike-timing dependence and putative network function. Frontiers in Neural Circuits 2013 7:119.
  5. Froemke RC, Carcea I, Barker AJ, Yuan K, Seybold B, Martins ARO, Zaika N, Bernstein H, Wachs M, Levis PA, Polley DB, Merzenich MM, Schreiner CE. Long-term modification of cortical synapses improves sensory perception. Nature Neuroscience 2013; 16:79-88. supplementary figures



  1. Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A. Intrinsically determined cell death of developing cortical interneurons. Nature 2012; 491:109-113. supplementary figures
  3. Hunzinger JF, Chan VH, Froemke RC. Learning complex temporal patterns with resource-dependent spike timing-dependent plasticity. Journal of Neurophysiology 2012; 108:551-566.



  1. Froemke RC, Martins ARO. Spectrotemporal dynamics of auditory cortical synaptic receptive field plasticity. Hearing Research 2011; 279:149-161.
  3. Froemke RC, Jones BJ. Development of auditory cortical synaptic receptive fields.  Neuroscience and Biobehavioral Reviews 2011; 35:2105-2113.


2010 and earlier

  1. Dorrn A, Yuan K, Barker AJ, Schreiner CE, Froemke RC. Developmental sensory experience balances cortical excitation and inhibition. Nature 2010; 465:932-936. supplementary figures
  3. Southwell D, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. Cortical plasticity induced by inhibitory neuron transplantation. Science 2010; 327:1145-1148. supplementary materials
  5. Froemke RC, Letzkus JJ, Kampa BM, Hang GB, Stuart GJ. Dendritic synapse location and neocortical spike-timing-dependent plasticity. Frontiers in Synaptic Neuroscience 2010; 2:29.
  7. Froemke RC, Debanne D, Bi GQ. Temporal modulation of spike-timing-dependent plasticity. Frontiers in Synaptic Neuroscience 2010; 2:19.
  9. Urakubo H, Honda M, Froemke RC, Kuroda S. Requirement on an allosteric kinetics of NMDA receptors for spike-timing-dependent plasticity. Journal of Neuroscience 2008; 28:3310-3323. supplementary materials
  11. Froemke RC, Merzenich MM, Schreiner, CE.  A synaptic memory trace for cortical receptive field plasticity.  Nature 2007; 450:425-429. supplementary materials
  13. Kenet T, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a non-coplanar PCB alters tonotopy, receptive fields and plasticity in rat primary auditory cortex.  Proceedings of the National Academy of Sciences USA 2007; 104:7646-7651. supplementary figures
  15. Froemke RC, Tsay IA, Raad M, Long JD, Dan Y.  Contribution of individual spikes in burst-induced long-term synaptic modification.  Journal of Neurophysiology 2006; 95:1620-1629.
  17. Froemke RC, Poo MM, Dan Y.  Spike-timing-dependent plasticity depends on dendritic location. Nature 2005; 434:221-225. supplementary data 
  19. Froemke RC, Dan Y.  Spike-timing-dependent synaptic modification induced by natural spike trains. Nature 2002; 416:433-438. 
  21. Beaumont V, Zhong N, Froemke RC, Ball RW, Zucker RS.  Temporal synaptic tagging by Ih activation and actin: involvement in long-term facilitation and cAMP-induced synaptic enhancement.  Neuron 2002; 33:601-613.
  23. Mao BQ, Hamzei-Sichani F, Aronov D, Froemke RC, Yuste R.  Dynamics of spontaneous activity in neocortical slices.  Neuron 2001; 32:883-898.
  25. Beaumont V, Zhong N, Fletcher R, Froemke RC, Zucker RS. Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation. Neuron 2001; 32:489-501.